data_FAM_000132 # _pdbx_reference_molecule_family.family_prd_id FAM_000132 _pdbx_reference_molecule_family.name "aspartate aldehyde containing tetrapeptide inhibitors" _pdbx_reference_molecule_family.release_status REL _pdbx_reference_molecule_family.replaces ? _pdbx_reference_molecule_family.replaced_by ? # loop_ _pdbx_reference_molecule_list.family_prd_id _pdbx_reference_molecule_list.prd_id FAM_000132 PRD_000241 FAM_000132 PRD_000259 FAM_000132 PRD_000282 FAM_000132 PRD_000284 FAM_000132 PRD_000293 FAM_000132 PRD_000300 FAM_000132 PRD_000301 FAM_000132 PRD_000976 # loop_ _pdbx_reference_molecule_synonyms.family_prd_id _pdbx_reference_molecule_synonyms.prd_id _pdbx_reference_molecule_synonyms.ordinal _pdbx_reference_molecule_synonyms.source _pdbx_reference_molecule_synonyms.name FAM_000132 PRD_000293 1 PDB AC-ESMD-CHO FAM_000132 PRD_000293 2 Scifinder "L-Methioninamide, N-acetyl-L-alpha-glutamyl-L-seryl-N-[(1S)-2-carboxy-1-formylethyl]-" FAM_000132 PRD_000293 3 PubChem "(4S)-4-acetamido-5-[[(2S)-3-hydroxy-1-[[(2S)-1-[[(2S)-4-hydroxy-1,4-dioxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid" FAM_000132 PRD_000282 4 Scifinder "L-Leucinamide, N-acetyl-L-alpha-aspartyl-L-asparaginyl-N-[(1S)-2-carboxy-1-formylethyl]-" FAM_000132 PRD_000282 5 PubChem Ac-DNLD-CHO FAM_000132 PRD_000282 6 PubChem "Caspase-3/7 Inhibitor" FAM_000132 PRD_000282 7 InhibitorSourceBook "Caspase-3/7 Inhibitor II" FAM_000132 PRD_000282 8 InhibitorSourceBook Ac-DNLD-CHO FAM_000132 PRD_000284 9 PDB AC-DQMD-CHO FAM_000132 PRD_000284 10 Scifinder "L-Methioninamide, N-acetyl-L-alpha-aspartyl-L-glutaminyl-N-[(1S)-2-carboxy-1-formylethyl]-" FAM_000132 PRD_000284 11 PubChem "(3S)-3-acetamido-4-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-4-hydroxy-1,4-dioxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-oxobutanoic acid" FAM_000132 PRD_000284 12 PubChem "(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4-hydroxy-4-oxobutanoyl]amino]-5-amino-5-oxopentanoyl]amino]-4-methylsulfanylbutanoyl]amino]butanedioic acid" FAM_000132 PRD_000300 13 Scifinder "L-Prolinamide, N-acetyl-L-isoleucyl-L-alpha-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-" FAM_000132 PRD_000300 14 PubChem Ac-IEPD-CHO FAM_000132 PRD_000300 15 PubChem "Granzyme B Inhibitor IV" FAM_000132 PRD_000300 16 PubChem "Caspase-8 inhibitor III" FAM_000132 PRD_000300 17 InhibitorSourceBook Ac-IEPD-CHO FAM_000132 PRD_000300 18 InhibitorSourceBook "Caspase-8 inhibitor III" FAM_000132 PRD_000300 19 PubChem "(4S)-4-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-5-[2-[[(2S)-4-hydroxy-1,4-dioxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-oxopentanoic acid" FAM_000132 PRD_000300 20 InhibitorSourceBook Ac-Ile-Glu-Pro-Asp-CHO FAM_000132 PRD_000301 21 PDB Ac-IETD-CHO FAM_000132 PRD_000301 22 Scifinder "L-Threoninamide, N-acetyl-L-isoleucyl-L-alpha-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-(9CI)" FAM_000132 PRD_000301 23 PubChem "Caspase-8 Inhibitor I" FAM_000132 PRD_000301 24 PubChem "Granzyme B Inhibitor II" FAM_000132 PRD_000301 25 eMolecules Ac-Ile-Glu-Thr-Asp-Aldehyde FAM_000132 PRD_000301 26 eMolecules Ac-Ile-Glu-Thr-Asp-CHO FAM_000132 PRD_000301 27 eMolecules N-Acetyl-Ile-Glu-Thr-Asp-al FAM_000132 PRD_000301 28 InhibitorSourceBook "Caspase-8 Inhibitor 1" FAM_000132 PRD_000301 29 InhibitorSourceBook Ac-Ile-Glu-Thr-Asp-CHO FAM_000132 PRD_000301 30 PubChem "(4S)-4-[[(2S,3S)-2-acetamido-3-methylpentanoyl]amino]-5-[[(2S,3S)-3-hydroxy-1-[[(2S)-4-hydroxy-1,4-dioxobutan-2-yl]amino]-1-oxobutan-2-yl]amino]-5-oxopentanoic acid" FAM_000132 PRD_000301 31 PubChem Ac-IETD-CHO FAM_000132 PRD_000301 32 PubChem Ac-Ile-Glu-Thr-Asp-CHO FAM_000132 PRD_000301 33 PubChem Ac-Ile-Glu-Thr-Asp-Aldehyde FAM_000132 PRD_000241 34 PDB "N-acetyl-L-leucyl-L-alpha-aspartyl-L-alpha-glutamyl-L-seryl-L-aspartic aldehyde" FAM_000132 PRD_000241 35 PDB Ac-LDESD-cho FAM_000132 PRD_000241 36 InhibitorSourceBook "Caspase-2 Inhibitor II" FAM_000132 PRD_000241 37 PubMed acetyl-Leu-Asp-Glu-Ser-Asp-aldehyde # loop_ _pdbx_reference_molecule_annotation.family_prd_id _pdbx_reference_molecule_annotation.prd_id _pdbx_reference_molecule_annotation.ordinal _pdbx_reference_molecule_annotation.source _pdbx_reference_molecule_annotation.type _pdbx_reference_molecule_annotation.text FAM_000132 PRD_000282 1 InhibitorSourceBook Function "tetrapeptidyl aldehyde that acts as an active site binding inhibitor of caspases-3 and -7" FAM_000132 PRD_000282 2 InhibitorSourceBook Function "activity against Camptothecin and anti-Fas-mediated apoptosis in Jurkat T cells" FAM_000132 PRD_000284 3 PMID:17697120 Function "CASPASE-7 INHIBITOR" FAM_000132 PRD_000293 4 PMID:17697120 Function "CASPASE-7 Inhibitor" FAM_000132 PRD_000300 5 InhibitorSourceBook Function "Reversible inhibitor of granzyme B and caspase-8" FAM_000132 PRD_000301 6 InhibitorSourceBook Function "Inhibitor of granzyme B, caspase-8, caspase-1, caspase-6, and caspase-10" FAM_000132 PRD_000301 7 MPbiochemicals Function "A potent, reversible inhibitor of granzyme B and caspase-8 (Ki = 1 nM). Also inhibits caspase-1 (<6 nM), caspase-6 (5.6 nM), and caspase-10 (27 nM)" FAM_000132 PRD_000241 8 InhibitorSourceBook Function "cell-permeable and irreversible inhibitor of caspase-2" FAM_000132 PRD_000259 9 PMID:17697120 Function "inhibitor of Caspase 7, EC: 3.4.22.60" # loop_ _pdbx_reference_molecule_features.family_prd_id _pdbx_reference_molecule_features.prd_id _pdbx_reference_molecule_features.ordinal _pdbx_reference_molecule_features.source_ordinal _pdbx_reference_molecule_features.source _pdbx_reference_molecule_features.type _pdbx_reference_molecule_features.value FAM_000132 PRD_000293 1 1 PubMed External_reference_ID 11398034 FAM_000132 PRD_000293 2 1 ChemSpider External_reference_ID 9572934 FAM_000132 PRD_000282 3 1 Beilstein External_reference_ID 10045742 FAM_000132 PRD_000282 4 1 PubChem External_reference_ID 10458686 FAM_000132 PRD_000282 5 1 ChemSpider External_reference_ID 8634100 FAM_000132 PRD_000282 6 1 CAS External_reference_ID 775289-20-8 FAM_000132 PRD_000282 7 1 Calbiochem External_reference_ID 218832 FAM_000132 PRD_000284 8 1 PubChem External_reference_ID 9984584 FAM_000132 PRD_000284 9 1 ChemSpider External_reference_ID 8160174 FAM_000132 PRD_000284 10 2 PubChem External_reference_ID 10460203 FAM_000132 PRD_000284 11 2 ChemSpider External_reference_ID 8635616 FAM_000132 PRD_000300 12 1 PubChem External_reference_ID 16760476 FAM_000132 PRD_000300 13 1 InhibitorSourceBook External_reference_ID 368056 FAM_000132 PRD_000300 14 1 CAS External_reference_ID 352520-90-2 FAM_000132 PRD_000300 15 1 InhibitorSourceBook Image http://structuresearch.merck-chemicals.com/cgi-bin/getStructureImage.pl?owner=EMD&unit=BIO&product=368056 FAM_000132 PRD_000301 16 1 MeSH MeSH_Unique_ID C401206 FAM_000132 PRD_000301 17 1 PubChem External_reference_ID 16760475 FAM_000132 PRD_000301 18 1 ChemSpider External_reference_ID 9641038 FAM_000132 PRD_000301 19 1 ChemDB External_reference_ID 9749449 FAM_000132 PRD_000301 20 1 InhibitorSourceBook External_reference_ID 368055 FAM_000132 PRD_000301 21 1 CAS External_reference_ID 191338-86-0 FAM_000132 PRD_000301 22 1 eMolecules URL http://www.emolecules.com/cgi-bin/more?vid=27274825 FAM_000132 PRD_000301 23 1 InhibitorSourceBook Image http://structuresearch.merck-chemicals.com/cgi-bin/getStructureImage.pl?owner=EMD&unit=BIO&product=368055 FAM_000132 PRD_000301 24 1 MPbiochemicals External_reference_ID AL012 FAM_000132 PRD_000301 25 2 PubChem External_reference_ID 44135117 FAM_000132 PRD_000301 26 1 ChEBI External_reference_ID 598855 FAM_000132 PRD_000301 27 2 ChemSpider External_reference_ID 9641038 FAM_000132 PRD_000301 28 3 PubChem External_reference_ID 11466200 FAM_000132 PRD_000301 29 1 BindingDB External_reference_ID 10357 FAM_000132 PRD_000241 30 1 InhibitorSourceBook External_reference_ID 218814 FAM_000132 PRD_000241 31 1 PubChem External_reference_ID 447969 # loop_ _pdbx_family_prd_audit.family_prd_id _pdbx_family_prd_audit.date _pdbx_family_prd_audit.processing_site _pdbx_family_prd_audit.action_type FAM_000132 2012-02-08 RCSB "Create family" FAM_000132 2013-10-16 RCSB "Initial release" #