data_FAM_000123 # _pdbx_reference_molecule_family.family_prd_id FAM_000123 _pdbx_reference_molecule_family.name "Ac-VTbLQcmph inhibitor" _pdbx_reference_molecule_family.release_status REL _pdbx_reference_molecule_family.replaces ? _pdbx_reference_molecule_family.replaced_by ? # loop_ _pdbx_reference_molecule_list.family_prd_id _pdbx_reference_molecule_list.prd_id FAM_000123 PRD_000250 # loop_ _pdbx_reference_molecule_synonyms.family_prd_id _pdbx_reference_molecule_synonyms.prd_id _pdbx_reference_molecule_synonyms.ordinal _pdbx_reference_molecule_synonyms.source _pdbx_reference_molecule_synonyms.name FAM_000123 PRD_000250 1 PDB acetyl-valyl-(O-benzyloxy)threonyl-leucyl-ketomethyl(cycloglutamine)-phthalhydrazide FAM_000123 PRD_000250 2 PDB Ac-VTbLQcmph # loop_ _pdbx_reference_molecule_annotation.family_prd_id _pdbx_reference_molecule_annotation.prd_id _pdbx_reference_molecule_annotation.ordinal _pdbx_reference_molecule_annotation.source _pdbx_reference_molecule_annotation.type _pdbx_reference_molecule_annotation.text FAM_000123 PRD_000250 1 PMID:17599357 function "inhibitor of Replicase polyprotein 1ab (pp1ab), EC: 3.4.22.-," FAM_000123 PRD_000250 2 PMID:17599357 "Mechanism of action" "form an unusual thiiranium ring with the nucleophilic sulfur atom of Cys145, trapping the enzyme's catalytic residues in configurations similar to the intermediate states" # loop_ _pdbx_family_prd_audit.family_prd_id _pdbx_family_prd_audit.date _pdbx_family_prd_audit.processing_site _pdbx_family_prd_audit.action_type FAM_000123 2012-02-08 RCSB "Create family" FAM_000123 2013-10-16 RCSB "Initial release" #