data_FAM_000089 # _pdbx_reference_molecule_family.family_prd_id FAM_000089 _pdbx_reference_molecule_family.name LEUPEPTIN _pdbx_reference_molecule_family.release_status REL _pdbx_reference_molecule_family.replaces ? _pdbx_reference_molecule_family.replaced_by ? # loop_ _pdbx_reference_molecule_list.family_prd_id _pdbx_reference_molecule_list.prd_id FAM_000089 PRD_000216 # loop_ _pdbx_reference_molecule_synonyms.family_prd_id _pdbx_reference_molecule_synonyms.prd_id _pdbx_reference_molecule_synonyms.ordinal _pdbx_reference_molecule_synonyms.source _pdbx_reference_molecule_synonyms.name FAM_000089 PRD_000216 1 PDB "N-acetyl(N-propionyl)-L-leucyl-L-leucyl-D L-argininal" FAM_000089 PRD_000216 2 PubChem "Leupeptin, Hemisulfate" FAM_000089 PRD_000216 3 PubChem Ac-LLR-CHO FAM_000089 PRD_000216 4 PubChem "2-Acetylamino-4-methyl-pentanoic acid [1-(1-formyl-4-guanidino-butylcarbamoyl)-3-methyl-butyl]-amide" FAM_000089 PRD_000216 5 PubChem 2-acetamido-N-[1-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide FAM_000089 PRD_000216 6 PubChem 2-(2-acetamido-4-methylvaleramido)-N-(1-formyl-4-guanidinobutyl)-4-methylvaleramide FAM_000089 PRD_000216 7 PubChem acetyl-L-leucyl-L-leucylargininal FAM_000089 PRD_000216 8 PubChem "L-leucinamide, N-acetyl-L-leucyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)-" FAM_000089 PRD_000216 9 PubChem leupeptin FAM_000089 PRD_000216 10 PubChem N-acetyl-L-leucyl-L-leucyl-L-argininal FAM_000089 PRD_000216 11 PubChem N-acetyl-L-leucyl-N-[(1R)-4-{[amino(imino)methyl]amino}-1-formylbutyl]-L-leucinamide FAM_000089 PRD_000216 12 PubChem NK-381 FAM_000089 PRD_000216 13 PubChem "valeramide, 2-(2-acetamido-4-methylvaleramido)-N-(1-formyl-4-guanidinobutyl)-4-methyl-" FAM_000089 PRD_000216 14 SciFinder Acetyl-L-leucyl-L-leucylargininal FAM_000089 PRD_000216 15 SciFinder "Leupeptin Ac-LL" FAM_000089 PRD_000216 16 SciFinder "Valeramide, 2-(2-acetamido-4-methylvaleramido)-N-(1-formyl-4-guanidinobutyl)-4-methyl- (8CI)" FAM_000089 PRD_000216 17 SciFinder "Leupeptin hemisulfate" # loop_ _pdbx_reference_molecule_annotation.family_prd_id _pdbx_reference_molecule_annotation.prd_id _pdbx_reference_molecule_annotation.ordinal _pdbx_reference_molecule_annotation.source _pdbx_reference_molecule_annotation.type _pdbx_reference_molecule_annotation.text FAM_000089 PRD_000216 1 Wikipedia Function "Leupeptin is a competitive inhibitor of serine and cysteine proteases reversibly. Leupeptin inhibits serine proteinases, trypsin, plasmin, porcine kallikrein, and cysteine proteinases, papain, cathepsin B, endoproteinase Lys-C. It does not inhibit chymotrypsin or thrombin." FAM_000089 PRD_000216 2 PubChem Function "A reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune responses of HIV+ donors." FAM_000089 PRD_000216 3 Merck Function "Class of modified protease inhibitors poroduced by various species of Actinomycetes." FAM_000089 PRD_000216 4 MEROPS Function ;The discovery of leupeptin in the late 1960s drew attention to the potential of aldehydes as peptidase inhibitors.Many aldehydes are now known as inhibitors of serine, cysteine or threonine peptidases. They form hemiacetal orthiohemiacetal conjugates with the essential hydroxyl or thiol group of the enzyme that are transition state analogues.The compounds exist predominantly in their hydrated forms in aqueous solution, but only the aldehyde is an effectiveinhibitor. Aldehydes can also act as inhibitors of metallopeptidases. Leupeptin is a slow, tight-binding, transitionstate analogue inhibitor of cathepsin B. Leupeptin inhibits a wide range of serine (families S1, S8), cysteine(families C1, C11) and threonine (family T1) peptidases. Apart from numerous peptidases in families S1 and C1,leupeptin is a potent inhibitor of clostripain C11.001 and PACE4 S08.075 and the trypsin-like activity of theproteasome T01.011 ; FAM_000089 PRD_000216 5 PMID:19128015 Function "Inhibitor of Cysteine Protease Falcipain-3, EC:3.4.22.-" FAM_000089 PRD_000216 6 PMID:17881000 Function "Inhibitor of Kallikrein-5, EC:3.4.21.-" FAM_000089 PRD_000216 7 DOI:10.2210/pdb2p0r/pdb Function "Inhibitor of Calpain-9; EC:3.4.22.52" FAM_000089 PRD_000216 8 PMID:16793521 Function "Inhibitor of Cysteine Proteinase EP-B 2, EC:3.4.22.-" FAM_000089 PRD_000216 9 PMID:16414069 Function "Inhibitor of alpha I Tryptase, EC:3.4.21.59" FAM_000089 PRD_000216 10 PMID:11893336 Function "Inhibitor of Calpain 1, EC:3.4.22.52" FAM_000089 PRD_000216 11 PMID:8845765 Function "Inhibitor of Trypsin, EC:3.4.21.4" FAM_000089 PRD_000216 12 PMID:8416808 Function "inhibitor of papain, EC: 3.4.22.2" # loop_ _pdbx_reference_molecule_features.family_prd_id _pdbx_reference_molecule_features.prd_id _pdbx_reference_molecule_features.ordinal _pdbx_reference_molecule_features.source_ordinal _pdbx_reference_molecule_features.source _pdbx_reference_molecule_features.type _pdbx_reference_molecule_features.value FAM_000089 PRD_000216 1 1 Wikipedia URL http://en.wikipedia.org/wiki/Leupeptin FAM_000089 PRD_000216 2 1 Labome.com URL http://www.labome.com/review/reagent/leupeptin.html FAM_000089 PRD_000216 3 1 CAS External_Reference_ID 103476-89-7 FAM_000089 PRD_000216 4 1 berkeley.edu URL http://potency.berkeley.edu/chempages/LEUPEPTIN.html FAM_000089 PRD_000216 5 1 PubChem External_Reference_ID 3910 FAM_000089 PRD_000216 6 1 ChEBI External_Reference_ID 109342 FAM_000089 PRD_000216 7 1 ChemBank External_Reference_ID 907367 FAM_000089 PRD_000216 8 1 ChemSpider External_Reference_ID 3773 FAM_000089 PRD_000216 9 1 Calbiochem External_Reference_ID 108975 FAM_000089 PRD_000216 10 1 ChemDB External_Reference_ID 3967241 FAM_000089 PRD_000216 11 1 KEGG KEGG_Compound_ID C01591 FAM_000089 PRD_000216 12 1 Merck External_Reference_ID 14:5456 FAM_000089 PRD_000216 13 1 MEROPS External_Reference_ID J00027 FAM_000089 PRD_000216 14 2 PubChem External_Reference_ID 439527 FAM_000089 PRD_000216 15 1 ChemIDplus External_Reference_ID 024365477 FAM_000089 PRD_000216 16 2 CAS External_Reference_ID 24365-47-7 FAM_000089 PRD_000216 17 1 MESH External_Reference_ID C032854 FAM_000089 PRD_000216 18 3 PubChem External_Reference_ID 3033938 FAM_000089 PRD_000216 19 1 BindingDB External_Reference_ID 12041 FAM_000089 PRD_000216 20 2 ChEBI External_Reference_ID 468978 FAM_000089 PRD_000216 21 2 ChemSpider External_Reference_ID 2298508 FAM_000089 PRD_000216 22 1 LeadScope External_Reference_ID LS-87930 FAM_000089 PRD_000216 23 1 Merck Image http://structuresearch.merck-chemicals.com/cgi-bin/getStructureImage.pl?owner=EMD&unit=BIO&product=108975 FAM_000089 PRD_000216 24 1 Nature Image http://www.nature.com/nchembio/journal/v4/n9/images/nchembio.104-comp15.gif # loop_ _pdbx_family_prd_audit.family_prd_id _pdbx_family_prd_audit.date _pdbx_family_prd_audit.processing_site _pdbx_family_prd_audit.action_type FAM_000089 2012-02-08 RCSB "Create family" FAM_000089 2013-10-16 RCSB "Initial release" #